货号 |
bsm-52462R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-Phospho-JNK1/2/3(T183+T183+T221) antibody |
中文名称 |
Rabbit Anti-Phospho-JNK1/2/3(T183+T183+T221) antibody |
产品标签 |
重组兔单抗 |
研究领域 |
肿瘤,信号转导,转录调节因子 |
英文别名 |
JNK1 + JNK2 + JNK3 (phospho T183 + T183 + T221); JNK1 (phospho T183); p-JNK1 (phospho T183); MAPK8 (phospho T183); JNK1 + JNK2 (phospho Thr183 + Thr183); JNK1 + 2 (phospho Thr183+Thr183); p-JNK; c Jun N terminal kinase 1; C-JUN kinase 1; EC 2.7.11.24; JAK |
反应物种(已验证) |
Human,Mouse,Rat |
产品应用(已验证) |
WB,IHC,ICC,FCM |
产品应用(可推荐) |
IP |
推荐稀释比例 |
WB=1:1000-2000,IP=1:20-50,IHC-P=1:50-200,IHC-F=1:50-200,Flow Cyt=1:100,ICC=1:50, |
克隆类型 |
单克隆 |
克隆号 |
6C10 |
抗体来源 |
Rabbit |
理论分子量 |
42 |
细胞定位 |
细胞核,细胞浆 |
性状 |
Lyophilized or Liquid |
免疫原 |
KLH conjugated Synthesised phosphopeptide derived from human JNK1/JNK2/JNK3 around the phosphorylation site of T183/T183/T221 |
抗原表位 |
MM(p-T)PY |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cytoplasm. Nucleus. |
SIMILARITY |
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Contains 1 protein kinase domain. |
Function |
Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress |
Post-translational |
Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme. Phosphorylated by TAOK2. |
SWISS |
P45983 |
Gene ID |
5599 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jun 2013] |