货号 |
bsm-54341R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-CYP26A1 antibody |
中文名称 |
Rabbit Anti-CYP26A1 antibody |
产品标签 |
重组兔单抗 |
研究领域 |
肿瘤,细胞生物,神经生物学,信号转导,新陈代谢, |
英文别名 |
CP26; CP26A_HUMAN; CYP26; CYP26A 1; cyp26a1; Cytochrome P450 26A1; Cytochrome P450 family 26 subfamily A polypeptide 1; Cytochrome P450 retinoic acid-inactivating 1; cytochrome P450, family 26, subfamily A, polypeptide 1; cytochrome P450, subfamily XXVIA, |
反应物种(已验证) |
Human |
反应物种(预测) |
Rat |
产品应用(已验证) |
WB,IHC |
产品应用(可推荐) |
ELISA |
推荐稀释比例 |
WB=1:500-1000,Elisa=1:5000-10000,IHC-P=1:50-200,IHC-F=1:50-200, |
克隆类型 |
单克隆 |
克隆号 |
11A1 |
抗体来源 |
Rabbit |
理论分子量 |
48 |
细胞定位 |
细胞浆,细胞膜 |
性状 |
Liquid |
免疫原 |
Recombinant human CYP26A1 |
抗原表位 |
200-400/497 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
Tissue |
Highest levels in adult liver, heart, pituitary gland, adrenal gland, placenta and regions of the brain. |
SIMILARITY |
Belongs to the cytochrome P450 family. |
Function |
Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation of several hydroxylated forms of RA, in |
SWISS |
O43174 |
Gene ID |
1592 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
The cytochrome P450 proteins (CYPs) are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. P450 enzymes are classified into subfamilies based on their sequence similarities. CYP26A1 is a major retinoic acid catabolic enzyme. CYP26A1 plays an important role in protecting tailbud tissues from inappropriate exposure to retinoic acid. CYP26A1 transcription is epigenetically regulated by nuclear retinoic acid receptor ∫2. Mutations in the gene encoding for CYP26A1 are associated with caudal agenesis and spina bifida, imperforate anus, agenesis of the caudal portions of the digestive and urogenital tracts, and malformed lumbosacral skeletal elements. CYP26A1 is upregulated in adenomatous polyposis coli mouse adenomas, human FAP adenomas, human sporadic colon carcinomas, and in the intestine of adenomatous polyposis coli (apcmcr) mutant zebrafish embryos. |