货号 |
bs-2833R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-phospho-FSCN1 (Ser39) antibody |
中文名称 |
Rabbit Anti-phospho-FSCN1 (Ser39) antibody |
产品标签 |
磷酸化抗体 |
研究领域 |
细胞生物,信号转导,结合蛋白, |
英文别名 |
Fascin (phospho Ser39); Fascin (phospho S39); 55 kDa actin bundling protein; Actin bundling protein; FAN 1; FAN1; Fascin 1; Fascin homolog 1 actin bundling protein (Strongylocentrotus purpuratus); Fascin homolog 1; Fascin1; FLJ38511; FSCN 1; FSCN1; HSN; p |
反应物种(已验证) |
Human,Mouse,Rat |
反应物种(预测) |
Dog,Pig |
产品应用(已验证) |
WB |
产品应用(可推荐) |
ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
55 |
细胞定位 |
细胞浆 |
性状 |
Liquid |
免疫原 |
KLH conjugated Synthesised phosphopeptide derived from human FSCN1 around the phosphorylation site of Ser39 |
抗原表位 |
AS(p-S)LK |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cytoplasm > cytoskeleton. Cell projection > filopodium. Cell projection > invadopodium. |
Tissue |
Ubiquitous. |
SIMILARITY |
Belongs to the fascin family. |
Function |
Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse |
Post-translational |
Phosphorylation on Ser-39 inhibits the actin-binding ability of fascin. |
SWISS |
Q16658 |
Gene ID |
6624 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
Human fascin is a highly conserved actin-bundling protein. Fascin, encoded by the human homolog for sn (hsn) gene, has been localized to microspikes and stress fibers of cultured cells where it is thought to be involved in the formation of microfilament bundles. It is expressed predominantly in dendritic cells. Lymphoid cells, myeloid cells and plasma cells are negative. However, Reed Sternberg cells in Hodgkin’s lymphoma are positive for fascin staining. Epstein-Barr virus may induce expression of fascin in B cells. |