免 疫 原：KLH conjugated Synthesised phosphopeptide derived from human FSCN1 around the phosphorylation site of Ser39
抗原表位：AS(p-S)LK
SWISS：Q16658
Gene ID ：6624
Human Gene ID：6624

Human fascin is a highly conserved actin-bundling protein. Fascin, encoded by the human homolog for sn (hsn) gene, has been localized to microspikes and stress fibers of cultured cells where it is thought to be involved in the formation of microfilament bundles. It is expressed predominantly in dendritic cells. Lymphoid cells, myeloid cells and plasma cells are negative. However, Reed Sternberg cells in Hodgkin’s lymphoma are positive for fascin staining. Epstein-Barr virus may induce expression of fascin in B cells.
Function：Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse
Subcellular Location：Cytoplasm > cytoskeleton. Cell projection > filopodium. Cell projection > invadopodium.
Tissue Specificity：Ubiquitous.
Post-translational modifications：Phosphorylation on Ser-39 inhibits the actin-binding ability of fascin.
Similarity：Belongs to the fascin family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.