货号 |
bs-2854R |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-SIK1 (phospho T182) + SIK2 (phospho T175) + SIK3 (phospho T221) antibody |
中文名称 |
Rabbit Anti-SIK1 (phospho T182) + SIK2 (phospho T175) + SIK3 (phospho T221) antibody |
研究领域 |
肿瘤,细胞生物,免疫学,信号转导,细胞周期蛋白,转录调节因子 |
英文别名 |
MSK; myocardial SNF1 like kinase; Salt inducible kinase 1; Salt-inducible protein kinase 1; Serine threonine protein kinase SNF1 like kinase 1; Serine threonine protein kinase SNF1LK; Serine/threonine-protein kinase SIK1; Serine/threonine-protein kinase S |
反应物种(已验证) |
Rat |
反应物种(预测) |
Human,Mouse,Chicken,Dog,Pig,Cow,Horse |
产品应用(已验证) |
WB |
推荐稀释比例 |
WB=1:500-2000, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
85 |
细胞定位 |
细胞核,细胞浆 |
性状 |
Lyophilized or Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human SIK1 (phospho T182) + SIK2 (phospho T175) + SIK3 (phospho T221) |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cytoplasm. Nucleus. |
SIMILARITY |
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily. Contains 1 protein kinase domain. Contains 1 UBA domain. |
SUBUNIT |
Interacts with ATP1A1 (By similarity). Interacts (when phosphorylated on Thr-182 and Ser-186) with YWHAZ. |
Function |
Serine/threonine-protein kinase involved in variousprocesses such as cell cycle regulation, gluconeogenesis andlipogenesis regulation, muscle growth and differentiation and tumorsuppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1,TORC1/CRTC1 and TORC2 |
Post-translational |
Phosphorylated at Thr-182 by STK11/LKB1 in complex withSTE20-related adapter-alpha (STRADA) pseudo kinase and CAB39,leading to its activation. Phosphorylation at Thr-182 promotesautophosphorylation at Ser-186, which is required for sustainedactivity. Auto |
DISEASE |
Note=Defects in SIK1 may be associated with some cancers,such as breast cancers. Loss of SIK1 correlates with poor patientoutcome in breast cancers (PubMed:19622832). |
SWISS |
P57059 |
Gene ID |
150094 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
Transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. Potential role in G2/M cell cycle regulation. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3. |