免 疫 原：KLH conjugated synthetic peptide derived from human SIK1 (phospho T182) + SIK2 (phospho T175) + SIK3 (phospho T221)
SWISS：P57059
Gene ID ：150094
Human Gene ID：150094

Transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. Potential role in G2/M cell cycle regulation. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3.
Function：Serine/threonine-protein kinase involved in variousprocesses such as cell cycle regulation, gluconeogenesis andlipogenesis regulation, muscle growth and differentiation and tumorsuppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1,TORC1/CRTC1 and TORC2
Subunit：Interacts with ATP1A1 (By similarity). Interacts (when phosphorylated on Thr-182 and Ser-186) with YWHAZ.
Subcellular Location：Cytoplasm. Nucleus.
Post-translational modifications：Phosphorylated at Thr-182 by STK11/LKB1 in complex withSTE20-related adapter-alpha (STRADA) pseudo kinase and CAB39,leading to its activation. Phosphorylation at Thr-182 promotesautophosphorylation at Ser-186, which is required for sustainedactivity. Auto
DISEASE：Note=Defects in SIK1 may be associated with some cancers,such as breast cancers. Loss of SIK1 correlates with poor patientoutcome in breast cancers (PubMed:19622832).
Similarity：Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.
Contains 1 protein kinase domain.
Contains 1 UBA domain.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.