货号 |
bsm-33855M-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Mouse Anti-Histone H3 (tri methyl K4) antibody |
中文名称 |
Mouse Anti-Histone H3 (tri methyl K4) antibody |
产品标签 |
甲基化抗体 |
研究领域 |
染色质和核信号,表观遗传学, |
英文别名 |
Histone H3 (tri methyl Lys4) ; H3K4me3;
H3 histone family member E pseudogene;
H3 histone family, member A;
H3/A;
H31_HUMAN;
H3F3;
H3FA;
Hist1h3a;
HIST1H3B;
HIST1H3C;
HIST1H3D;
HIST1H3E;
HIST1H3F;
HIST1H3G;
HIST1H3H;
HIST1H3I;
HIST1H3J;
H |
反应物种(已验证) |
Human |
反应物种(预测) |
Mouse,Rat |
产品应用(已验证) |
WB |
产品应用(可推荐) |
IHC |
推荐稀释比例 |
WB=1:500-1000,IHC-P=1:200-500, |
克隆类型 |
单克隆 |
克隆号 |
3D10 |
抗体来源 |
Mouse |
理论分子量 |
15 |
细胞定位 |
细胞核 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthesised methylpeptide derived from human Histone H3 around the methylation site of Tri Methyl K4 |
抗原表位 |
RT(Tri Methyl-K)QT |
亚型 |
IgG1 |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Nucleus; Chromosome |
Tissue |
Expressed in testicular cells.Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation. |
SIMILARITY |
Belongs to the histone H3 family. |
SUBUNIT |
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. |
Function |
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replic |
Post-translational |
Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by E |
SWISS |
P68431 |
Gene ID |
8350 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015] |