货号 |
bs-0646R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-CD34 antibody |
中文名称 |
Rabbit Anti-CD34 antibody |
研究领域 |
肿瘤,心血管,免疫学,发育生物学,神经生物学,干细胞,细胞表面分子,糖蛋白,细胞类型标志物(Neuron marker, Soma marker, Myeloid Cells),血管内皮细胞,内皮细胞, |
英文别名 |
CD34 antigen; CD34 molecule; Cluster designation 34; Hematopoietic progenitor cell antigen CD34; HPCA1; CD34_HUMAN. |
反应物种(已验证) |
Human,Mouse |
反应物种(预测) |
Rat,Dog,Pig,Cow,Rabbit |
产品应用(已验证) |
WB,IHC,ICC,IF,FCM |
产品应用(可推荐) |
ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,Flow Cyt=1μg/Test,IF=1:200-800, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
39 |
细胞定位 |
细胞膜 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human CD34 |
抗原表位 |
301-385/385 |
抗原细胞定位 |
Extracellular |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Membrane; Single-pass type I membrane protein. |
Tissue |
Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. |
SIMILARITY |
Belongs to the CD34 family. |
Function |
Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing |
Post-translational |
Highly glycosylated.
Phosphorylated on serine residues by PKC. |
SWISS |
P28906 |
Gene ID |
947 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
The highly glycosylated 75-120 kD antigen CD34 is possibly an adhesion molecule with a putative role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. It could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C, suggesting a putative role in signal transduction. Two isoforms of CD34 have been reported to be generated by alternative splicing. CD34 is highly expressed on hematopoietic progenitors, as well as on endothelial cells, brain, and testis. Staining for CD34 has been used to measure angiogenesis, which reportedly predicts tumor recurrence. |