货号 |
bs-0878R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-CD144/VE Cadherin antibody |
中文名称 |
Rabbit Anti-CD144/VE Cadherin antibody |
研究领域 |
肿瘤,心血管,免疫学,信号转导,细胞粘附分子,血管内皮细胞,上皮细胞,内皮细胞,细胞外基质, |
英文别名 |
VE-cadherin; 7B4 antigen; VECD; Vascular endothelial cell cadherin; 7B 4; 7B4; 7B4 antigen; Cadherin 5; Cadherin 5 type 2; Cadherin-5; Cadherin5; CD 144; CD144 antigen; CDH 5; CDH5; CDH5 protein; Vascular endothelial cadherin; VE Cad antibody VEC; CADH5_H |
反应物种(已验证) |
Human,Mouse,Rat |
产品应用(已验证) |
WB,IHC,IF,FCM |
产品应用(可推荐) |
ICC,ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,Flow Cyt=1μg /test,IF=1:100-500,ICC=1:100, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
86 |
细胞定位 |
细胞膜 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from mouse Vascular endothelial cell cadherin |
抗原表位 |
601-700/784 |
抗原细胞定位 |
Cytoplasmic |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cell junction. Cell membrane. Found at cell-cell boundaries and probably at cell-matrix boundaries. |
Tissue |
Endothelial tissues and brain. |
SIMILARITY |
Contains 5 cadherin domains. |
SUBUNIT |
Interacts via cadherin 5 domain with PTPRB. Interacts with TRPC4. Interacts with KRIT1. |
Function |
Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important r |
Post-translational |
Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB. |
SWISS |
P55284 |
Gene ID |
12562 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]. |