免 疫 原：KLH conjugated synthetic peptide derived from mouse Vascular endothelial cell cadherin
抗原表位：601-700/784
抗原细胞定位：Cytoplasmic
SWISS：P55284
Gene ID ：12562
Human Gene ID：1003

This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008].
Function：Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important r
Subunit：Interacts via cadherin 5 domain with PTPRB. Interacts with TRPC4. Interacts with KRIT1.
Subcellular Location：Cell junction. Cell membrane. Found at cell-cell boundaries and probably at cell-matrix boundaries.
Tissue Specificity：Endothelial tissues and brain.
Post-translational modifications：Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB.
Similarity：Contains 5 cadherin domains.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.