货号 |
bs-10027R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-NCR1 antibody |
中文名称 |
Rabbit Anti-NCR1 antibody |
研究领域 |
细胞生物,免疫学,信号转导,转录调节因子 |
英文别名 |
Natural killer cell p46-related protein; Natural cytotoxicity triggering receptor 1; NK-p46; NKp46; NK cell-activating receptor; Lymphocyte antigen 94 homolog; CD335; CD 335; LY94; NCTR1_HUMAN. |
反应物种(已验证) |
Human,Mouse,Rat |
反应物种(预测) |
Dog,Pig,Cow,Horse,Sheep |
产品应用(已验证) |
WB |
产品应用(可推荐) |
ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
31 |
细胞定位 |
细胞膜 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human CD335 |
抗原表位 |
198-206/304 |
抗原细胞定位 |
Extracellular |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cell membrane. |
Tissue |
Selectively expressed by both resting and activated NK cells. |
SIMILARITY |
Belongs to the natural cytotoxicity receptor (NCR) family.
Contains 2 Ig-like (immunoglobulin-like) domains. |
SUBUNIT |
Interacts with CD247 and FCER1G |
Function |
Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. |
Post-translational |
N-glycosylated.
O-glycosylated. |
SWISS |
O76036 |
Gene ID |
9437 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. NCR1 is a glycoprotein that has two extracellular Ig-like domains followed by a ~40 amino acid residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. NCR1 has been shown to represent a novel NK cell-specific molecule involved in human NK cell activation. NCR1 has been implicated in NK cell-mediated lysis of several autologous tumor cells and pathogen-infected cell lines. |