免 疫 原：KLH conjugated synthetic peptide derived from human CD335
抗原表位：198-206/304
抗原细胞定位：Extracellular
SWISS：O76036
Gene ID ：9437
Human Gene ID：9437

The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. NCR1 is a glycoprotein that has two extracellular Ig-like domains followed by a ~40 amino acid residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. NCR1 has been shown to represent a novel NK cell-specific molecule involved in human NK cell activation. NCR1 has been implicated in NK cell-mediated lysis of several autologous tumor cells and pathogen-infected cell lines.
Function：Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.
Subunit：Interacts with CD247 and FCER1G
Subcellular Location：Cell membrane.
Tissue Specificity：Selectively expressed by both resting and activated NK cells.
Post-translational modifications：N-glycosylated.
O-glycosylated.
Similarity：Belongs to the natural cytotoxicity receptor (NCR) family.
Contains 2 Ig-like (immunoglobulin-like) domains.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.