货号 |
bs-6044R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-DLL4 antibody |
中文名称 |
Rabbit Anti-DLL4 antibody |
研究领域 |
细胞生物,免疫学,神经生物学,细胞周期蛋白,细胞膜受体 |
英文别名 |
DeltaD; delta4; delta-like 4 (Drosophila); delta-like 4 homolog (Drosophila); Drosophila Delta homolog 4; delta-like 4 homolog; delta-like 4 protein; Aei; After eight; dld; DLL4_HUMAN; Delta-like protein 4; Drosophila Delta homolog 4; Delta 4 precursor; d |
反应物种(已验证) |
Human,Mouse |
反应物种(预测) |
Rat,Dog,Pig,Cow,Horse |
产品应用(已验证) |
WB,IHC |
产品应用(可推荐) |
IF,ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
72 |
细胞定位 |
细胞膜 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human DLL4 |
抗原表位 |
551-650/685 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Membrane; Single-pass type I membrane protein (Probable). |
Tissue |
Expressed in vascular endothelium. |
SIMILARITY |
Contains 1 DSL domain.
Contains 8 EGF-like domains. |
SUBUNIT |
Binds to Notch-1 and Notch-4 (By similarity). |
Function |
Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4. |
Post-translational |
Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation. |
SWISS |
Q9NR61 |
Gene ID |
54567 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
The LIN-12/Notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. Notch proteins have been found to be overexpressed or rearranged in human tumors. Ligands for Notch include Jagged, Jagged-2 and Delta. While blocking the differentiation of progenitor cells into the B-cell lineage, Delta promotes the emergence of a population of cells with T cell/NK-cell characteristics. The protein is a membrane protein expressed in heart, pancreas, brain and muscle during gastrulation and early organogenesis and in adult heart and lung. Delta-4 is a membrane protein that activates Notch-1 and Notch-4. It is expressed in a wide range of adult and fetal tissues, especially in vascular endothelium. |