免 疫 原：KLH conjugated synthetic peptide derived from human A2AR
抗原表位：165-300/412
抗原细胞定位：Cytoplasmic
SWISS：P29274
Gene ID ：135
Human Gene ID：135

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]
Function：Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Subunit：Interacts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct. May interact with DRD4.
Subcellular Location：Cell membrane; Multi-pass membrane protein.
Similarity：Belongs to the G-protein coupled receptor 1 family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.