免 疫 原：KLH conjugated synthetic peptide derived from human PLAUR
抗原表位：201-300/335
SWISS：Q03405
Gene ID ：5329
Human Gene ID：5329

This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol(GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq].
Function：Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA
Subcellular Location：Isoform 1: Cell membrane; Lipid-anchor, GPI-anchor. Isoform 2: Secreted (Probable).
Tissue Specificity：Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.
Similarity：Contains 3 UPAR/Ly6 domains.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.