| Rabbit Anti-Integrin alpha 6 antibody |
| 反应物种（预测） |
Mouse,Rat,Chicken,Cow |
| 产品应用（已验证） |
WB |
| 产品应用（可尝试） |
IHC,ELISA |
| 推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500, |
| 研究领域 |
细胞生物,免疫学,信号转导,干细胞,细胞粘附分子,淋巴细胞,B-淋巴细胞, |
| 标签 |
Array |
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Sample:
Lane 1: SW480 (Human) Cell Lysate at 30 ug
Lane 2: A549 (Human) Cell Lysate at 30 ug
Lane 3: Huvec (Human) Cell Lysate at 30 ug
Lane 4: A431 (Human) Cell Lysate at 30 ug
Primary: Anti-Integrin alpha 6 (bs-2641R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 120 kD
Observed band size: 115 kD
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Sample: A549 Cell (Human) Lysate at 40 ug
Primary: Anti-Integrin alpha 6 (bs-2641R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 21/124 kD
Observed band size: 130 kD
RRID：AB_10855326
产品名称：Rabbit Anti-Integrin alpha 6 antibody
别名： Integrin alpha-6; Alpha6p; VLA 6 alpha subunit; VLA 6; VLA-6; Integrin α6;
CD49 antigen-like family member F;
CD49f;
Integrin alpha6B;
Integrin, alpha 6;
ITA6_HUMAN;
ITGA6;
ITGA6B;
Processed integrin alpha-6.
中文名称：整合素α6（CD49f）抗体
英文名称：Rabbit Anti-Integrin alpha 6 antibody
抗体来源： Rabbit
克隆类型：多克隆
细胞定位：细胞膜
性 状：Liquid
亚 型：IgG
纯化方法：affinity purified by Protein A
保存条件：Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
免 疫 原：KLH conjugated synthetic peptide derived from human Integrin alpha 6
抗原表位：1031-1130/1130
抗原细胞定位：Cytoplasmic
SWISS：P23229
Gene ID ：3655
Human Gene ID：3655
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Function：Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome.
Subunit：Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 or beta-4. Interacts with HPS5. Interacts with RAB21.
Subcellular Location：Cell membrane; Single-pass type I membrane protein.
Tissue Specificity：Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limite
Post-translational modifications：Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affin
DISEASE：Defects in ITGA6 are a cause of epidermolysis bullosa letalis with pyloric atresia (EB-PA) [MIM:226730]; also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is an aut
Similarity：Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
400-901-9800
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