免 疫 原：KLH conjugated synthetic peptide derived from human CD27
抗原表位：201-260/260
SWISS：P26842
Gene ID ：939
Human Gene ID：939

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]
Function：Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.
Subunit：Homodimer. Interacts with SIVA1 and TRAF2.
Subcellular Location：Membrane; Single-pass type I membrane protein.
Tissue Specificity：Found in most T-lymphocytes.
Post-translational modifications：Phosphorylated.
O-glycosylated with core 1 or possibly core 8 glycans.
Similarity：Contains 3 TNFR-Cys repeats.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.