免 疫 原：KLH conjugated synthetic peptide derived from human SUR1
抗原表位：301-400/1581
抗原细胞定位：Extracellular
SWISS：Q09428
Gene ID ：6833
Human Gene ID：6833

SUR1 is a member of ATP binding cassette super family. SUR receptor confers the sensitivity of Kir6.2 to ATP/ADP sensitivity and to pharmacological agents such as sulfonylurea and diazoxide that close or open the KATP channels. The persistent heyperinsulinimic hypoglycemia in infancy (PHHI) is familial disorder due to defect in negative feed back in response to low glucose levels. SUR1 was mapped on chromosome 11p14-15.1, the same location where the gene for PHHI is located. It has been shown that the expression of Kir6.2 and SUR1 are regulated by glucose levels and the actives of glucogon like peptide receptor 1. Abnormal insulin secretion in PHHI appears to be caused by mutations in the SUR gene.
Subunit：Interacts with KCNJ11.
Subcellular Location：Membrane; Multi-pass membrane protein.
Similarity：Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Contains 2 ABC transmembrane type-1 domains.
Contains 2 ABC transporter domains.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.