| Rabbit Anti-TRF2 antibody |
| 反应物种（预测） |
Rat,Dog,Pig,Rabbit |
| 产品应用（已验证） |
IHC,ICC |
| 产品应用（可尝试） |
IF,ELISA |
| 推荐稀释比例 |
Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100, |
| 研究领域 |
肿瘤,转录调节因子,表观遗传学, |
| 标签 |
Array |
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Paraformaldehyde-fixed, paraffin embedded (Human colon cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Telomeric repeat binding protein 2 ) Polyclonal Antibody, Unconjugated (bs-1922R) at 1:400 overnight at 4°C, followed by a conjugated secondary antibody (sp-0023) for 20 minutes and DAB staining.
RRID：AB_10855576
产品名称：Rabbit Anti-TRF2 antibody
别名： Telomeric DNA binding protein; Telomeric repeat binding factor 2; Telomeric repeat binding protein 2; TERF 2; TERF2; TRBF 2; TRBF2; TRF 2; TTAGGG repeat binding factor 2.
中文名称：端粒结合蛋白2抗体
英文名称：Rabbit Anti-TRF2 antibody
抗体来源： Rabbit
克隆类型：多克隆
细胞定位：细胞核
性 状：Liquid
亚 型：IgG
纯化方法：affinity purified by Protein A
保存条件：Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
免 疫 原：KLH conjugated synthetic peptide derived from human TRF2
抗原表位：301-400/500
SWISS：Q15554
Gene ID ：7014
Human Gene ID：7014
This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. [provided by RefSeq, Jul 2008]
Function：Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and en
Subcellular Location：Nucleus. Chromosome, telomere. Colocalizes with telomeric DNA in interphase cells and is located at chromosome ends during metaphase.
Tissue Specificity：Ubiquitous. Highly expressed in spleen, thymus, prostate, uterus, testis, small intestine, colon and peripheral blood leukocytes.
Post-translational modifications：Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity：Contains 1 HTH myb-type DNA-binding domain.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
400-901-9800
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