免 疫 原：KLH conjugated synthetic peptide derived from human SGLT1
抗原表位：401-500/665
SWISS：Q8C3K6
Gene ID ：6523
Human Gene ID：6523

This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Function：Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capaci
Subcellular Location：Membrane; Multi-pass membrane protein.
Tissue Specificity：Expressed mainly in intestine and kidney.
Post-translational modifications：N-glycosylation is not necessary for the cotransporter function.
DISEASE：Congenital glucose/galactose malabsorption (GGM) [MIM:606824]: Intestinal monosaccharide transporter deficiency. It is an autosomal recessive disorder manifesting itself within the first weeks of life. It is characterized by severe diarrhea and dehydratio
Similarity：Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.