免 疫 原：KLH conjugated synthetic peptide derived from human CD161
抗原表位：151-225/225
抗原细胞定位：Extracellular
SWISS：Q12918
Gene ID ：3820
Human Gene ID：3820

Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008]
Function：Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinas
Subunit：Contains 1 C-type lectin domain.
Subcellular Location：Membrane.
Tissue Specificity：Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype.
Post-translational modifications：N-glycosylated. Contains sialic acid residues.
Similarity：Contains 1 C-type lectin domain.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.