免 疫 原：KLH conjugated synthetic peptide derived from human eIF4E
抗原表位：121-217/217
SWISS：P06730
Gene ID ：1977
Human Gene ID：1977

eIF4E, a protein modulates translation of maternal mRNAs in early embryos before the onset of zygotic transcription. eIF4E also influences the overall rate of translation. eIF4E binds to the 7 methyl GTP cap structure of eukaryotic mRNAs. Phosphorylation of eIF4E on serine 209 regulates the affinity of this protein for the 7 methyl GTP cap and/or RNA. Phosphorylation also enhances the interaction of eIF4E with eIF4G, which form a complex known as eIF4F. eIF4E phosphorylation is correlated with increased translational rate in a number of cell types. Several kinases are currently being investigated as potential regulators of eIF4E including PKC and/or the MAP kinase activated Mnk.
Function：Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome bi
Subunit：eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4E is also known to interact with other partners. The interaction with EIF
Subcellular Location：Cytoplasm, P-body.
Post-translational modifications：Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the eIF4F complex.
Similarity：Belongs to the eukaryotic initiation factor 4E family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.