免 疫 原:KLH conjugated synthetic peptide derived from human ID1
抗原表位:51-155/155
SWISS:P41134
Gene ID :3397
Human Gene ID:3397
ID proteins contain a helix-loop-helix (HLH) motif and regulate tissue-specific transcription within several cell lineages. They do not bind DNA directly, but inhibit lineage commitment by binding basic helix-loop-helix (bHLH) transcription factors through their HLH motif. ID proteins contribute to cell growth, senescence, differentiation and angiogenesis. Id1 mRNA is highly expressed in heart, lung and kidney and has lower expression in brain and liver. Two transcript variants encoding different isoforms have been found for this gene.
Function:ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding.
Subunit:Heterodimer with other HLH proteins. Interacts with COPS5.
Subcellular Location:Cytoplasm. Nucleus.
Similarity:Contains 1 bHLH (basic helix-loop-helix) domain.
Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.