| Rabbit Anti-PAI1 antibody |
| 反应物种（预测） |
Rat,Dog,Pig,Cow,Horse,Sheep,GuineaPig |
| 产品应用（已验证） |
IHC,IF |
| 产品应用（可尝试） |
WB,ELISA |
| 推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500, |
| 研究领域 |
肿瘤,心血管,细胞生物,激酶和磷酸酶,肿瘤细胞生物标志物, |
| 标签 |
Array |
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Tissue/cell: mouse intestine tissue;4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-PAI1/PLANH1/Serpine-1 Polyclonal Antibody, Unconjugated(bs-6562R) 1:200, overnight at 4°C; The secondary antibody was Goat Anti-Rabbit IgG, Cy5 conjugated (bs-0295G-Cy5)used at 1:200 dilution for 40 minutes at 37°C. DAPI(5ug/ml,blue,C-0033) was used to stain the cell nuclei
RRID：AB_11114126
产品名称：Rabbit Anti-PAI1 antibody
别名： Clade E; Endothelial plasminogen activator inhibitor; Nexin; PAI 1; PAI; PAI-1; PAI1_HUMAN; PLANH1; Plasminogen activator inhibitor 1; Plasminogen activator inhibitor type 1; Serine (or cysteine) proteinase inhibitor; Serpin E1; Serpin peptidase inhibitor
中文名称：内皮细胞纤溶酶原激活抑制蛋白1抗体
英文名称：Rabbit Anti-PAI1 antibody
抗体来源： Rabbit
克隆类型：多克隆
细胞定位：细胞外基质,分泌型蛋白
性 状：Liquid
亚 型：IgG
纯化方法：affinity purified by Protein A
保存条件：Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
免 疫 原：KLH conjugated synthetic peptide derived from human PAI1/PLANH1
抗原表位：251-350/402
SWISS：P05121
Gene ID ：5054
Human Gene ID：5054
This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis.
Function：Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.
Subunit：Forms protease inhibiting heterodimer with TMPRSS7. Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation.
Subcellular Location：Secreted.
Tissue Specificity：Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells
DISEASE：Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1D) . It is a hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due t
Similarity：Belongs to the serpin family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
400-901-9800
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