免 疫 原：KLH conjugated synthetic peptide derived from human ANG5/ANGPTL3
抗原表位：21-120/460
SWISS：Q9Y5C1
Gene ID ：27329
Human Gene ID：27329

Angiopoietin-like protein 3 (Angptl3) functions as a potent lipoprotein lipase inhibitor and is an important component of plasma triglyceride homeostasis. Angptl3 also plays a role in adipose formation and angiogenesis through its interaction with integrin ?v)beta(3). It is secreted by the liver and is functionally defined by the C-terminal fibrinogen (FBN)-like domain and an N-terminal coiled-coil domain. Angptl3 regulates circulating triglyceride levels during different nutritional states thereby mediating the feeding/fasting cycle. A deficiency of Angptl3 results in abnormally low lipid levels, and a repression of the protein may be protective against atherosclerosis. Angptl3 may also play an important role in hyperlipidemia in diabetes.
Subcellular Location：Secreted
Tissue Specificity：Expressed principally in liver. Weakly expressed in kidney.
Similarity：Contains 1 fibrinogen C-terminal domain.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.