| Rabbit Anti-MYLIP antibody |
| 反应物种（预测） |
Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit |
| 产品应用（已验证） |
WB |
| 产品应用（可尝试） |
ELISA |
| 推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000, |
| 研究领域 |
心血管,细胞生物,信号转导,细胞周期蛋白,细胞骨架,表观遗传学, |
| 标签 |
Array |
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Sample:
Jurkat(Human) Cell Lysate at 30 ug
Primary: Anti- MYLIP (bs-9674R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 49 kD
Observed band size: 53 kD
RRID：RRID
产品名称：Rabbit Anti-MYLIP antibody
别名： BZF1; E3 ubiquitin protein ligase MYLIP; E3 ubiquitin-protein ligase MYLIP; Idol; Inducible degrader of the LDL-receptor; Idol; MIR; MYLIP; MYLIP_HUMAN; Myosin regulatory light chain interacting protein.
中文名称：低密度脂蛋白受体的诱导降解蛋白抗体
英文名称：Rabbit Anti-MYLIP antibody
抗体来源： Rabbit
克隆类型：多克隆
细胞定位：细胞浆
性 状：Liquid
亚 型：IgG
纯化方法：affinity purified by Protein A
保存条件：Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
免 疫 原：KLH conjugated synthetic peptide derived from human MYLIP
抗原表位：51-150/445
SWISS：Q8WY64
Gene ID ：29116
Human Gene ID：29116
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.
Function：E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counter
Subunit：Interacts with myosin regulatory light chain (MRLC) and TMEM4.
Subcellular Location：Cytoplasm.
Tissue Specificity：Ubiquitously expressed.
Post-translational modifications：Autoubiquitinated.
Similarity：Contains 1 FERM domain.
Contains 1 RING-type zinc finger.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
400-901-9800
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