免 疫 原：KLH conjugated synthetic peptide derived from human NSF
抗原表位：151-250/744
SWISS：P46459
Gene ID ：4905
Human Gene ID：4905

Several protein-protein interactions are essential to membrane fusion during endocytosis. Membrane fusion requires interaction among SNARE1 proteins associated with both donor and acceptor membranes (1,2). Following membrane fusion, the α-SNAP cytoplasmic adapter protein binds to the SNARE complex. N-ethylmaleimide-sensitive factor (NSF), a hexameric ATPase, then associates with the α-SNAP/SNARE complex to mediate SNARE disassembly during membrane fusion (3,4). The ATPase activity of NSF induces a conformational change in the α-SNAP/SNARE complex that leads to its dissociation from the membrane, membrane fusion and eventual recycling of the SNARE complex for subsequent membrane fusion (3,4).
Function：Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seem to function as a fusion protein required for the deliver
Subunit：Homohexamer. Interacts with GABARAP and GABARAPL2. Interacts with GRIA2. Interacts with PLK2, leading to disrupt the interaction with GRIA2. Interacts with MUSK; may regulate MUSK endocytosis and activity (By similarity). Interacts with CDK16 (By similari
Subcellular Location：Cytoplasm.
Post-translational modifications：Phosphorylation at Ser-569 interferes with homohexamerization (By similarity).
Similarity：Belongs to the AAA ATPase family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.