免 疫 原：KLH conjugated Synthesised phosphopeptide derived from human GFAP around the phosphorylation site of Ser8
抗原表位：IT(p-S)A
SWISS：P14136
Gene ID ：2670
Human Gene ID：2670

This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Function：GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
Subunit：Interacts with SYNM. Isoform 3 interacts with PSEN1 (via N-terminus).
Subcellular Location：Cytoplasm.
Tissue Specificity：Expressed in cells lacking fibronectin.
Post-translational modifications：Phosphorylated by PKN1.
DISEASE：Defects in GFAP are a cause of Alexander disease (ALEXD) [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are
Similarity：Belongs to the intermediate filament family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.