免 疫 原：KLH conjugated Synthesised phosphopeptide derived from human HSF1 around the phosphorylation site of Ser307
抗原表位：PQ(p-S)PR
SWISS：Q00613
Gene ID ：3297
Human Gene ID：3297

The product of this gene is a heat-shock transcription factor. Transcription of heat-shock genes is rapidly induced after temperature stress. Hsp90, by itself and/or associated with multichaperone complexes, is a major repressor of this gene. [provided by RefSeq, Jul 2008].
Function：DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher ukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.
Subunit：Monomer. Under normal conditions, interacts with HSP90AA1 in the HSP90 multichaperone complex; the interaction prevents trimerization and activation of HSF1. On activation by heat-stress or by other factors such as metal ions, HSF1 is released from the co
Subcellular Location：Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth. On activation, translocates to nuclear stress granules. Colocalizes with SUMO1 in nuclear stress granules.
Post-translational modifications：Phosphorylated on multiple serine residues, a subset of which are involved in stress-related regulation of transcription activation. Constitutive phosphorylation represses transcriptional activity at normal temperatures. Levels increase on specific residu
Similarity：Belongs to the HSF family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.