免 疫 原：KLH conjugated synthetic peptide derived from human STK38
抗原表位：31-130/465
SWISS：Q15208
Gene ID ：11329
Human Gene ID：11329

STK38 belongs to the NDR family of serine/threonine protein kinases. NDR kinases require the phosphorylation of conserved Ser/Thr residues for activation. NDR family members have two unique stretches of primary sequence: an N-terminal regulatory (NTR) domain and an insert of several residues between subdomains VII and VIII of the kinase domain. The kinase domain insert functions as an auto-inhibitory sequence (AIS), while binding of the co-activator MOB (Mps-one binder) proteins to the NTR domain releases NDR kinases from inhibition of autophosphorylation. STK38 negatively regulates the activation of MEKK1/2 by direct interaction with the catalytic domain of MEKK1/2. The negative regulation of MEKK1/2 is not due to its phosphorylation by STK38.
Function：Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its nonphosphorylated form and inhibits autophosphorylation of MAP3K2.
Subunit：Homodimeric S100B binds two molecules of STK38.
Subcellular Location：Nucleus. Cytoplasm.
Tissue Specificity：Ubiquitously expressed with highest levels observed in peripheral blood leukocytes.
Post-translational modifications：ISGylated (Probable).
Phosphorylated by STK3/MST2 and this is enhanced by MOBKL1B.
Similarity：Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. Contains 1 AGC-kinase C-terminal domain. Contains 1 protein kinase domain.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.