| Rabbit Anti-phospho-GluR1 (Ser836) antibody |
| 反应物种（预测） |
Human,Mouse,Rat |
| 产品应用（已验证） |
FCM |
| 产品应用（可尝试） |
ELISA |
| 推荐稀释比例 |
Elisa=1:5000-10000,Flow Cyt=1ug/Test, |
| 研究领域 |
肿瘤,细胞生物,免疫学,神经生物学,信号转导,细胞凋亡,转录调节因子 |
| 标签 |
Array |
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Blank control:SH-SY5Y.
Primary Antibody (green line): Rabbit Anti-phospho-GluR1 (Ser836) antibody (bs-8454R)
Dilution: 1ug/Test;
Secondary Antibody : Goat anti-rabbit IgG-FITC
Dilution: 0.5ug/Test.
Protocol
The cells were incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.
RRID：RRID
产品名称：Rabbit Anti-phospho-GluR1 (Ser836) antibody
别名： Glutamate Receptor 1 (phospho S836); Glutamate Receptor 1 (phospho Ser836); p-GluR1(Ser836); p-GluR1(r836); GLUR 1; GLUR A; AMPA 1; AMPA selective glutamate receptor 1; GLUH 1; GLUH1; GluR K1; GluR-1; GluR-A; GluR-K1; GLUR1; GLURA ; GluRK1; Glutamate rece
中文名称：磷酸化谷氨酸受体1抗体
英文名称：Rabbit Anti-phospho-GluR1 (Ser836) antibody
抗体来源： Rabbit
克隆类型：多克隆
细胞定位：细胞浆,细胞膜,细胞外基质
性 状：Liquid
亚 型：IgG
纯化方法：affinity purified by Protein A
保存条件：Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
免 疫 原：KLH conjugated synthesised phosphopeptide derived from human GluR1 around the phosphorylation site of Ser836
抗原表位：SE(p-S)KR
SWISS：P42261
Gene ID ：2890
Human Gene ID：2890
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Function：Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation ch
Subunit：Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with DLG1 via its C-terminus. Interacts with SYNDIG1 and GRIA2. Interacts with LRFN. Interacts with HIP1 and RASGR
Subcellular Location：Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic dens
Tissue Specificity：Widely expressed in brain.
Post-translational modifications：Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-depende
Similarity：Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA1 subfamily.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
400-901-9800
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