免 疫 原：KLH conjugated Synthesised phosphopeptide derived from human RCC1 around the phosphorylation site of Ser11
抗原表位：RR(p-S)PP
SWISS：P18754
Gene ID ：1104
Human Gene ID：1104

Ran GTPase plays important roles in nucleocytoplasmic transport in interphase and in both spindle formation and nuclear envelope (NE) assembly during mitosis. The latter functions rely on the presence of high local concentrations of GTP bound Ran near mitotic chromatin. RanGTP localization has been proposed to result from the association of Ran's GDP/GTP exchange factor, RCC1, with chromatin , but Ran is shown here to bind directly to chromatin in two modes, either dependent or independent of RCC1, and, where bound, to increase the affinity of chromatin for NE membranes.
Function：Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with o
Subunit：Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation.
Subcellular Location：Nucleus. Cytoplasm. Note=Becomes dispersed throughout the cytoplasm during mitosis.
Post-translational modifications：N-terminal methylation by METTL11A/NTM1 is required for binding double-stranded DNA and stable chromatin association. Di-and trimethylation produce a permanent positive charge on the amino group, which facilitate electrostatic binding to the phosphate gro
Similarity：Contains 7 RCC1 repeats.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.