Rabbit Anti-phospho-GABBR1 (Ser923) antibody |
反应物种(预测) |
Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,GuineaPig |
产品应用(可尝试) |
ELISA |
推荐稀释比例 |
Elisa=1:5000-10000, |
研究领域 |
免疫学,神经生物学,细胞膜受体 |
标签 |
Array |
RRID:AB_11116186
产品名称:Rabbit Anti-phospho-GABBR1 (Ser923) antibody
别名: GABBR1 (phospho S1180); GABBR1 (phospho Ser1180); p-GABBR1 (Ser1180); GABAb Receptor 1; dJ271M21.1.1; dJ271M21.1.2; FLJ92613; GAB B R1; GABA B R1; GABAB R1; GABAB subunit 1c; GABAB(1e); GABABR 1; GABABR1; GABB R1; GABBR 1; GABBR1 3; GABBR1; Gamma aminobut
中文名称:磷酸化gamma氨基丁酸B型受体1抗体
英文名称:Rabbit Anti-phospho-GABBR1 (Ser923) antibody
抗体来源: Rabbit
克隆类型:多克隆
细胞定位:细胞膜,分泌型蛋白
性 状:Liquid
亚 型:IgG
纯化方法:affinity purified by Protein A
保存条件:Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
免 疫 原:KLH conjugated Synthesised phosphopeptide derived from human GABBR1 around the phosphorylation site of Ser923
抗原表位:R(p-S)RR
SWISS:Q9UBS5
Gene ID :2550
Human Gene ID:2550
Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jun 2009].
Function:Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipi
Subunit:Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Isoform 1E (without C-terminal intracellular domain) is unable to dimerize via a coiled-coil interaction with GABA-B-R2. Int
Subcellular Location:Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Colocalizes with ATF4 in hippocampal neuron dendritic membranes (By similarity). Moreover coexpression of GABA-B-R1 and GABA-
Tissue Specificity:Highly expressed in brain and weakly in heart, small intestine and uterus. Isoform 1A is mostly expressed in granular cell and molecular layer. Isoform 1B is mostly expressed in Purkinje cells. Isoform 1E is predominantly expressed in peripheral tissues a
Similarity:Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
Contains 2 Sushi (CCP/SCR) domains.
Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.