免 疫 原：KLH conjugated synthesised phosphopeptide derived from human alpha Adducin around the phosphorylation site of Ser436
抗原表位：RH(p-S)FQ
SWISS：P35611
Gene ID ：118
Human Gene ID：118

Adducins are a family of cytoskeleton proteins encoded by three genes (Alpha, Beta, Gamma). Adducin is a protein associated with the inner leaflet of the plasma membrane and is one of the proteins localized at the spectrin-actin junction of the membrane skeleton. The cortical actin cytoskeletal network is lost during apoptosis and Adducins are central in the cortical actin network organization. Adducin Alpha is a cytoskeletal protein involved with sodium-pump activity in the renal tubule and is associated with hypertension. The expression of Adducin Alpha and Adducin Gamma is ubiquitous in contrast to the restricted expression of Adducin Beta. Adducin Beta is expressed at high levels in brain and hematopoietic tissues, such as bone marrow, in humans, and in spleen in mice.
Function：Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
Subunit：Heterodimer of an alpha and a beta subunit or an alpha and a gamma subunit.
Subcellular Location：Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Tissue Specificity：Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit.
Similarity：Belongs to the aldolase class II family. Adducin subfamily.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.