Rabbit Anti-phospho-GABBR2 (Ser884) antibody |
反应物种(预测) |
Dog,Pig,Cow,Horse,Rabbit,Sheep,GuineaPig |
产品应用(已验证) |
WB |
产品应用(可尝试) |
IHC,ICC,IF,ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
研究领域 |
细胞生物,神经生物学,细胞膜受体 |
标签 |
Array |
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Sample:
Cerebrum (Mouse) Lysate at 40 ug
Cerebrum (Rat) Lysate at 40 ug
Primary: Anti- phospho-GABBR2 (Ser884) (bs-13258R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 104 kD
Observed band size: 104 kD
RRID:RRID
产品名称:Rabbit Anti-phospho-GABBR2 (Ser884) antibody
别名: GABA B Receptor 2 (phospho S884); p-GABA B Receptor 2 (phospho S884); p-GABBR2 (Ser884) ; GABBR2; GB2; G protein coupled receptor 51; G-protein coupled receptor 51; GAB B R2; GABA B R2; GABA B receptor 2; GABA B RECEPTOR; GABA-B receptor 2; GABA-B-R2; GAB
中文名称:磷酸化G氨基丁酸B型受体2抗体
英文名称:Rabbit Anti-phospho-GABBR2 (Ser884) antibody
抗体来源: Rabbit
克隆类型:多克隆
细胞定位:细胞膜
性 状:Liquid
亚 型:IgG
纯化方法:affinity purified by Protein A
保存条件:Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
免 疫 原:KLH conjugated Synthesised phosphopeptide derived from human GABBR2 around the phosphorylation site of Ser884
抗原表位:IN(p-S)PE
SWISS:O75899
Gene ID :9568
Human Gene ID:9568
The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010].
Function:Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipi
Subunit:Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Interacts with ATF4 via its C-terminal region.
Subcellular Location:ell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the
Tissue Specificity:Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in hear
Similarity:Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.