免 疫 原：KLH conjugated synthesised phosphopeptide derived from human MCSF Receptor around the phosphorylation site of Tyr561
抗原表位：NS(p-Y)TF
SWISS：P07333
Gene ID ：1436
Human Gene ID：1436

This protein tyrosine kinase transmembrane receptor is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a member of the CSF1/PDGF receptor family of tyrosine protein kinases and contains 5 immunoglobulin like C2 type domains. CD115 is expressed by cells of the monocytic lineage and by progenitor cells. Mutations in this gene have been associated with a predisposition to myeloid malignancy.
Function：Protein tyrosine-kinase transmembrane receptor for CSF1 and IL34.
Subcellular Location：Membrane.
Tissue Specificity：Expressed in bone marrow and in differentiated blood mononuclear cells.
Similarity：Belongs to the protein kinase superfamily.
Tyr protein kinase family.
CSF-1/PDGF receptor subfamily.
Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.