免 疫 原：KLH conjugated synthesised phosphopeptide derived from human PAK1 around the phosphorylation site of Ser204
抗原表位：TR(p-S)VI
SWISS：Q13153
Gene ID ：5058
Human Gene ID：5058

This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Function：The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complex
Subcellular Location：Cytoplasm. Cell junction > focal adhesion. Recruited to focal adhesions upon activation.
Post-translational modifications：Autophosphorylated when activated by CDC42/p21 and RAC1.
Similarity：Belongs to the protein kinase superfamily.
STE Ser/Thr protein kinase family. STE20 subfamily.
Contains 1 CRIB domain.
Contains 1 protein kinase domain.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.