免 疫 原：KLH conjugated synthetic peptide derived from human CD43
抗原表位：101-200/400
抗原细胞定位：Extracellular
SWISS：P16150
Gene ID ：6693
Human Gene ID：6693

This gene encodes a highly sialylated glycoprotein that functions in antigen-specific activation of T cells, and is found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It contains a mucin-like extracellular domain, a transmembrane region and a carboxy-terminal intracellular region. The extracellular domain has a high proportion of serine and threonine residues, allowing extensive O-glycosylation, and has one potential N-glycosylation site, while the carboxy-terminal region has potential phosphorylation sites that may mediate transduction of activation signals. Different glycoforms of this protein have been described. In stimulated immune cells, proteolytic cleavage of the extracellular domain occurs in some cell types, releasing a soluble extracellular fragment. Defects in expression of this gene are associated with Wiskott-Aldrich syndrome. [provided by RefSeq, Sep 2017]
Function：One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude a
Subunit：Interacts with HIPK2 via the cytoplasmic domain. Interacts with RDX.
Subcellular Location：Membrane; Single-pass type I membrane protein.
Tissue Specificity：Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.
Post-translational modifications：Glycosylated; has a high content of sialic acid and O-linked carbohydrate structures.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.