| Mouse Anti-CBARA1/MICU1 antibody |
| 反应物种（预测） |
Mouse,Rat |
| 产品应用（已验证） |
WB |
| 推荐稀释比例 |
WB=1:500-1000, |
| 研究领域 |
细胞生物,信号转导,新陈代谢,线抗体, |
| 标签 |
Array |
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Sample:
Lane 1: A549 (Human) Cell Lysate at 30 ug
Lane 2: U937 (Human) Cell Lysate at 30 ug
Lane 3: U87MG (Human) Cell Lysate at 30 ug
Lane 4: HepG2 (Human) Cell Lysate at 30 ug
Primary: Anti- CBARA1/MICU1 (bsm-33198M) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution
Predicted band size: 54/46 kD
Observed band size: 54/46 kD
RRID：RRID
产品名称：Mouse Anti-CBARA1/MICU1 antibody
别名： Mitochondrial Calcium Uptake 1;
Calcium-Binding Atopy-Related Autoantigen 1;
Atopy-Related Autoantigen CALC;
Ara CALC;
CBARA1;
CALC;
Calcium Binding Atopy-Related Autoantigen 1;
Calcium Uptake Protein 1, Mitochondrial;
Allergen Hom S 4;
EFHA3;
M
中文名称：线粒体钙吸收蛋白单克隆抗体
英文名称：Mouse Anti-CBARA1/MICU1 antibody
抗体来源： Mouse
克隆类型：单克隆
细胞定位：细胞浆
性 状：Liquid
亚 型：IgG
纯化方法：affinity purified by Protein G
保存条件：Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
免 疫 原：Recombinant human CBARA1 Protein (1-250/476)
SWISS：Q9BPX6
Gene ID ：10367
Human Gene ID：10367
This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2013]
Function：Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:269032
Subunit：Homohexamer; in absence of calcium (PubMed:24514027). Forms a homohexamer in absence of calcium and rearranges into a heterodimer in presence of calcium (PubMed:26489515, PubMed:24514027). Heterodimer; disulfide-linked; heterodimerizes with MICU2 (PubMed:
Subcellular Location：Mitochondrion inner membrane; Single-pass membrane protein; Mitochondrion intermembrane space
Tissue Specificity：Expressed in epithelial cell lines. Strongly expressed in epidermal keratinocytes and dermal endothelial cells.
Similarity：Belongs to the MICU1 family. MICU1 subfamily.
Contains 2 EF-hand domains.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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