Mouse Anti-c-fos antibody |
产品应用(已验证) |
WB |
推荐稀释比例 |
WB=1:500-2000, |
研究领域 |
肿瘤,细胞生物,免疫学,神经生物学,信号转导,转录调节因子 |
标签 |
Array |
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Sample:
Lung (Mouse) Lysate at 40 ug
Primary: Anti-c-fos (bsm-33204M) at 1/2 000 dilution
Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution
Predicted band size: 41 kD
Observed band size: 50 kD
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Sample:
Adrenal glands(Mouse) Lysate at 40 ug
MCF-7(Human) Cell Lysate at 30 ug
Uterus(Mouse) Lysate at 40 ug
Uterus(Rat) Lysate at 40 ug
Thyroid gland (Mouse) Lysate at 40 ug
Thyroid gland (Rat) Lysate at 40 ug
Primary: Anti- c-fos (bsm-33204M) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti- Mouse IgG at 1/20000 dilution
Predicted band size: 62/46 kD
Observed band size: 46 kD
RRID:RRID
产品名称:Mouse Anti-c-fos antibody
别名: Cellular oncogene fos; FBJ murine osteosarcoma viral v fos oncogene homolog antibody FBJ Osteosarcoma Virus; FOS; FOS protein; G0 G1 switch regulatory protein 7; G0S7; Oncogene FOS; Proto oncogene protein c fos; v fos FBJ murine osteosarcoma viral oncogen
中文名称:c-fos单克隆抗体
英文名称:Mouse Anti-c-fos antibody
抗体来源: Mouse
克隆类型:单克隆
细胞定位:细胞核,细胞浆
性 状:Liquid
亚 型:IgG
纯化方法:affinity purified by Protein G
保存条件:Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
免 疫 原:Recombinant human c-fos Protein
SWISS:P01100
Gene ID :2353
Human Gene ID:2353
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008].
Function:Nuclear phosphoprotein which forms a tight butnon-covalently linked complex with the JUN/AP-1 transcriptionfactor. In the heterodimer, FOS and JUN/AP-1 basic regions eachseems to interact with symmetrical DNA half sites. On TGF-betaactivation, forms a mul
Subunit:Heterodimer; with JUN (By similarity). Interacts withMAFB. Component of the SMAD3/SMAD4/JUN/FOS complexrequired for syngernistic TGF-beta-mediated transcription at theAP1 promoter site. Interacts with SMAD3; the interaction is weakeven on TGF-beta activat
Subcellular Location:Nucleus.
Post-translational modifications:Phosphorylated in the C-terminal upon stimulation by nervegrowth factor (NGF) and epidermal growth factor (EGF).Phosphorylated, in vitro, by MAPK and RSK1. Phosphorylation on bothSer-362 and Ser-374 by MAPK1/2 and RSK1/2 leads to proteinstabilization with
Similarity:Belongs to the bZIP family. Fos subfamily.
Contains 1 bZIP domain.
Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.