免 疫 原：Full length native Transferrin protein purified from human plasma
SWISS：P02787
Gene ID ：7018
Human Gene ID：7018

This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009].
Function：Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage
Subunit：Monomer.
Subcellular Location：Secreted.
Tissue Specificity：Expressed by the liver and secreted in plasma.
DISEASE：Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:209300]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.
Similarity：Belongs to the transferrin family.
Contains 2 transferrin-like domains.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.