免 疫 原：KLH conjugated synthetic peptide derived from mouse NQO1
抗原表位：201-274/274
SWISS：Q64669
Gene ID ：18104
Human Gene ID：1728

This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq].
Function：The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues
Subunit：Homodimer.
Subcellular Location：Cytoplasm.
Similarity：Belongs to the NAD(P)H dehydrogenase (quinone) family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.