免 疫 原：KLH conjugated synthetic peptide derived from human ACE2
抗原表位：351-450/805
抗原细胞定位：Extracellular
SWISS：Q9BYF1
Gene ID ：59272
Human Gene ID：59272

The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008].
Function：Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of
Subunit：Interacts with ITGB1. Interacts with SARS-CoV and HCoV-NL63 spike glycoprotein.
Subcellular Location：Processed angiotensin-converting enzyme 2: Secreted.
Cell membrane; Single-pass type I membrane protein.
Tissue Specificity：Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidn
Post-translational modifications：N-glycosylation on Asn-90 may limit SARS infectivity.
Proteolytic cleavage by ADAM17 generates a secreted form.
Belongs to the peptidase M2 family.
Similarity：Belongs to the peptidase M2 family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.