Mouse Anti-human CD4 antibody |
反应物种(预测) |
Human |
产品应用(已验证) |
FCM |
研究领域 |
肿瘤,细胞生物,免疫学,细胞表面分子,T-淋巴细胞, |
标签 |
Array |
RRID:RRID
产品名称:Mouse Anti-human CD4 antibody
别名: LHR; BA-1; CD 44; CD44 antigen; CD44 molecule; CD44_HUMAN; CDw44; Cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; ECMR-III; Epican; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; hematopoietic cell E- and
中文名称:小鼠抗人CD4单克隆抗体
英文名称:Mouse Anti-human CD4 antibody
抗体来源: Mouse
克隆类型:单克隆
细胞定位:细胞膜
性 状:Liquid
亚 型:Mouse IgG2b
纯化方法:Affinity purified by Protein G
保存条件:Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
免 疫 原:KLH conjugated synthetic peptide derived from human CD4
SWISS:P01730
This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010].
Function:Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
Subunit:Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid
Subcellular Location:Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expressi
Post-translational modifications:Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.