免 疫 原：Recombinant Streptolysin O
Human Gene ID：Streptolysin O

Streptolysin is a streptococcal hemolytic exotoxin. Types include streptolysin O (SLO), which is oxygen-labile, and streptolysin S (SLS), which is oxygen-stable. An antibody, antistreptolysin O, can be detected in an antistreptolysin O titre. Streptolysin O is hemolytically active only in a reversibly reduced state, unlike streptolysin S, which is stable in the presence of oxygen. Another difference is that SLO is antigenic, while SLS is not antigenic due to its small size. The main function of streptolysin O is to cause hemolysis (the breaking open of red blood cells) — in particular, beta-hemolysis. Increased levels of aso titre in the blood could cause damage to the heart and joints. In most cases, penicillin is used to treat patients with increased levels of aso titre.
Function：Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation o
Subunit：Homooligomeric pore complex; when inserted in the host membrane.
Subcellular Location：Secreted; Host cell membrane.
Similarity：Belongs to the thiol-activated cytolysin family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.