免 疫 原：KLH conjugated synthetic peptide derived from mouse MCT2
抗原表位：411-478/478
抗原细胞定位：Cytoplasmic
SWISS：O70451
Gene ID ：20503
Human Gene ID：9194

Tissues with few or no mitochondria, such as erythrocytes and tumor cells, depend largely on glycolysis to generate ATP. The major end products of glycolysis, pyruvate and lactate, must be eliminated from these cells to enable continued glycolytic flux and prevent toxic effects. H+/monocarboxylate transporters (MCTs) mediate the transport of lactate and pyruvate. Human MCT2 has a high affinity for the transport of pyruvate (summary by Lin et al., 1998 [PubMed 9786900]).[supplied by OMIM, Feb 2011].
Function：Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetat
Subunit：Interacts with GRID2IP.
Subcellular Location：Cell membrane; Multi-pass membrane protein.
Tissue Specificity：High expression in testis, moderate to low in spleen, heart, kidney, pancreas, skeletal muscle, brain and Leukocyte. Restricted expression in normal tissues, but widely expressed in cancer cells.
Similarity：Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.