免 疫 原：KLH conjugated synthetic peptide derived from human YAP1
抗原表位：51-150/504
SWISS：P46937
Gene ID ：10413
Human Gene ID：10413

This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction. [provided by RefSeq].
Function：Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferat
Subunit：Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds, in vitro, through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif (By similarity). The phosphorylated form interacts with YWHAB. Interacts (via WW domains) wi
Subcellular Location：Cytoplasm. Nucleus.
Tissue Specificity：Increased expression seen in some liver and prostate cancers. Isoforms lacking the transactivation domain found in striatal neurons of patients with Huntington disease (at protein level).
Similarity：Belongs to the YORKIE family.
Contains 2 WW domains.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.