免 疫 原：KLH conjugated synthetic peptide derived from human Glucose 6 phosphatase 2
抗原表位：191-290/355
SWISS：Q9NQR9
Gene ID ：57818
Human Gene ID：57818

Glucose-6-phosphatase (G6Pase), is a multicomponent enzyme system that hydrolyzes glucose-6-phosphate in the final step of gluconeogenesis and gluconeolysis. G6Pase localizes to the endoplasmic reticulum, and while liver, kidney, and intestine are the only tissues that express the first identified isoform, G6Pase-alpha, a second form, designated G6Pase-∫, contributes to blood glucose homeostasis in a wider range of tissues. Islet-specific G-6-Pase catalytic subunit-related protein (IGRP), a homolog of the catalytic subunit of G6Pase, may play a role in the regulation of islet metabolism and in insulin secretion induced by metabolites. The exact catalytic acivity of IGRP is not defined. Identification of inhibitors of IGRP have potential therapeutic benefits for treatment of type 2 diabetes resulting from insulin secretion defects. Structurally, IGRP has been shown to be a glycoprotein held in the endoplasmic reticulum by nine transmembrane domains, which are then degraded in cells through the proteasome pathway generating MHC class I presented peptides.
Function：IGRP (islet specific glucose 6 phosphatase catalytic subunit related protein), also known as G6PC2, belongs to the glucose-6-phosphatase catalytic subunit family. These enzymes are part of a multicomponent integral membrane system that catalyses the hydro
Subcellular Location：Endoplasmic reticulum membrane; Multi-pass membrane protein.
Tissue Specificity：Specifically expressed in pancreas and also detected to a lower extent in testis. Expressed by most islet cells in the pancreas (at protein level).
Post-translational modifications：N-glycosylated; the non-glycosylated form is more unstable and is degraded through the proteasome.
Similarity：Belongs to the glucose-6-phosphatase family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.