免 疫 原：KLH conjugated synthetic peptide derived from human Caspase-6
SWISS：P55212
Gene ID ：839
Human Gene ID：839

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008]
Function：Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
Subunit：Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce.
Subcellular Location：Cytoplasm.
Post-translational modifications：Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits.
Similarity：Belongs to the peptidase C14A family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.