免 疫 原：Recombinant human Fbx32
抗原表位：1-200/355
SWISS：Q969P5
Gene ID ：114907
Human Gene ID：114907

Fbx32 is an E3 ubiquitin ligase that initiates ATP dependent ubiquitin-mediated proteolysis and promotes muscle atrophy. It is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. It is also thought to recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation during skeletal muscle atrophy. Fbx32 interacts with MyoD by ubiquitination via a sequence found in transcriptional coactivators and therefore may play an important role in the course of muscle differentiation by determining the abundance of MyoD.
Function：Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins
Subunit：Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO32) formed of CUL1, SKP1, RBX1 and FBXO32.
Subcellular Location：Cytoplasm. Nucleus. Note=Shuttles between Cytoplasm and the nucleus.
Tissue Specificity：Specifically expressed in cardiac and skeletal muscle.
Similarity：Contains 1 F-box domain.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.